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How VR Can Be Used in a Care Home Setting for People with Dementia

Introduction

Dementia is a decline in cognition in one or more of the following capabilities:1

  • learning,
  • memory,
  • language,
  • attention,
  • executive decisions,
  • motor perception, and/or
  • social skills.

For clinical relevance, these deficits must be documentable as compared to the previous unimpaired activities of daily living (ADL). Documentation is typically a tally of the obvious, since caretakers and loved ones will bring patients to healthcare professionals after noticing the declines themselves. Often the above deficits blend.

Dementia represents a continuum of insidious onset and relentless progression, from mild cognitive impairment (MCI) to more advanced cognitive impairment (dementia). The earlier stages, MCI, present challenges since they can arise from non-organic sources, such as depression, side effects of medication, or acute illness. These latter causes are often reversible, but to date there has been very little success in reversing—or even stabilising—progression through the continuum to overt dementia. This failure is a result of actual organic illness (physical disease) causing the problem, and failure to impact the organic illness portends poorly for impacting dementia positively.

Public Enemy Number One

As the population ages, dementia becomes more important since 60-80% of cases are due to Alzheimer disease, technically an organic illness characterised by the accumulation of amyloid beta plaque deposition and tangles of tau protein (p-tau). The plaques are thought to be a problem with efficient turnover (production and removal) as a consequence of aging in those genetically predisposed; the p-tau is thought to be an immunoreactivity of aging neurons. Vascular involvement is another cofactor as vascular brain injury adds diminished oxygenation to the mix. Superimposed additional risks include hypertension (which begins and worsens with aging), abnormal lipids (diet-related), Type-2 diabetes and obesity (age-related), second-hand smoke exposure, and diminished physical activity.

Therapy and research for reversing or stabilising Alzheimer disease has therefore focused on altering the brain’s cholesterol metabolism, reducing the presence of amyloid beta plaques and p-tau tangles, and addressing cardiovascular contributions to the disease.

Never the Twain Shall Meet

Dementia can occur due to both organic or psychiatric mental illness, which are designated as separate distinctions. The psychiatric division of dementia is identified readily because it presents as more than mere dysfunctions of cognition: there is often a disconnect from reality. Regardless, in both the end result falls together along the bullet list of characteristics listed above. Medical approaches for organic illness and psychiatric approaches for psychiatric illness can overlap, making any judgment of efficacy for a particular therapy confusing.2 In short, it is as if the science of treating dementia has dementia.

Often the Twain Shall Meet

The human brain is each person’s universe. Perception of the laws of physics—sight, hearing, touch, balance, etc.—is what creates a unique universe for each of us. The collection of neurons and their interactions with each other makes each person’s ability to relate to others’ “universes” unique. Nevertheless, in different persons the cell structures are the same; the neurotransmitters are the same; the self-awareness/consciousness is the same. It makes sense, therefore, to offer a common re-learning process to those who lose the connections that store what has been learned over a lifetime—either from organic or from psychiatric dysfunction.

Wonder-deprived

If one were to reverse engineer the human mind, from that of the aged to childhood, what is lost from the mind is as easily identified as the loss of coordination, strength, and agility. Learning turns out to be very important when measured in what has been lost at advanced ages from what been learned in youth. As such, the deficit of memory is a particularly cruel bullet point (above).

The mind is our consciousness separate from the mere consortium of nerve cells and neurotransmitters. The sum is greater than the addition of parts and we rise above just the data to navigate our universes—inside, outside, and in co-existing with others. One of the most powerful embodiments of this is the childhood capacity to wonder. Wonder is learning.3

Because of the organic deterioration of these parts of the brain and the subsequent psychiatric dysfunction in the more primitive, emotional parts of the brain, the different tasks that address wonder fail to perceive it as wonder. Instead, the faulty processing is a dead end: no wonder, no “ride,” no learning, no collaborative volitional activities of daily living—physically, rationally, or socially. Memory of unrelated items (e.g., names in a phone book) is difficult even in those who have no deficits!

Building a New Ride

What if a different universe via virtual reality (VR) were presented in which the presentation was deemed trustworthy and safe?

When one rides a rollercoaster, danger is perceived by our primitive brains. Speed, centrifugal forces, and unnatural gravitational sensations are entered for processing. However, our rational brain recognises the science and safeguards and centripetal containment (seat belts or bar restraints) that make fools of the primitive parts. The battle between the two is the real impact of the ride: it is a thrill—both fight and flight at the same time. The thrill of danger in a guaranteed safe environment makes for the complex psychological result: fun. Fun adds an entirely different set of neurotransmitters4 to cognition, processing, and even learning.

Swapping out universes via the immersion of virtual reality means the presentation can be altered and controlled. Those who retain enough orientation will know that the new universe is a “safe” environment contained in a wearable display. This allows wonder and learning, and learning rewires the brain in a process called neuroplasticity.5

Those who are so dysfunctional that immersion into a different virtual environment cannot be separated from their false perceptions of actual reality require more work, along traditional routes, until their perception allows this different “safe” reality to proceed and restore their sense of wonder, fun, and learning. The strength of VR is that it can be authored, perhaps as an environment a patient with dementia will remember (identify with) as safe. For example, a familiar place depicted years earlier with the conventional presentations of the times—model-year cars that are familiar, previous urban landscapes, etc. In this way, virtual reality is not a replacement for traditional approaches, but a valid adjunct that can potentiate them. Reality Orientation (RO)6 trials have already shown that re-learning can positively impact mood and self-esteem; self-esteem is especially important in one’s quality of life,7 because the hopelessness of dementia-related confusion puts self-esteem in extreme jeopardy and engenders depression8,9 which can fuel a vicious cycle.

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Immergo, Ergo Sum: I Immerse, Therefore I Am

Awareness of self in space and time is consciousness, and suspension of disbelief can be cultivated so that those with cognitive deficits can embark on the “ride” of discovery, learning, and wonder, apply the experience into the familiar mental pathways, and reinforce via neuroplasticity what may have become a lost process. What VR therapy promises is a return to a safer time in someone’s mindset, when things were not confusing, nonsensical, or seemingly dangerous; when self-actualisation becomes its own reward and the reward, brokered via the right neurotransmitters, can rekindle one’s smoldering ashes into a better clarity.

Targets
  • Learning

The brain’s anatomy is designed to take unknown, new, or unrelated things and make sense out of them. This “ride” is wonder, and addressing novel presentations is how the brain learns, sorts out and organises itemised incongruities, and stores them into memory for retrieval on-the-fly when needed.

  • Memory

Memory is the retention of what has been learned. In his book, “The Brain that Changes Itself,” Norman Doidge states, “Neurons that fire together, wire together.”10 VR has the advantage of convenience, not constrained to classes, timed events, or presence. User-operated, it allows repetition until the desired effect—memory and learning—is hard-wired.11

  • Language

Language is communication. Patients who experience language deficits are similar to children with autism in which the parts for deciphering symbols, associating them with what they represent, and developing an innate equating of them with objects or intangibles becomes disjointed. The repetitive reinforcement of language and what words mean is the first step, which becomes the foundation for syntactical appreciation for what is being conveyed. For example, a sentence is in a sense a mere list of words; however, how they’re arranged and how they’re appended with prefixes and suffixes gives sense to the sentence. If firing together wires together neurons, then repetition is the ideal method for language and the learning and memory upon which it depends. So much in life is how, why, when, and what that there is no overemphasising nouns, adjectives, verbs, adverbs, and prepositions. A lost art, diagramming sentences, can be overlaid on a VR immersion as actions ensue.

  • Attention

Attention depends on engagement. VR offers immersive presentations through which patients can engage. The VR environment can be individualised for different deficits of attention, using “attractors” specific patients find engaging. Attention potentiates learning, memory, and language.

  • Motor Perception

VR can be authored for specific movements that will strengthen proprioception (reducing falls) and purposeful movements. In the human brain, “mirror” motor neurons fire whether an action is seen, heard, or performed. This portends well for benefits of VR and advancement from see-and-hear to perform.12

  • Social Skills

There are rules of society just as there are rules of physics. If VR can be used to navigate the universe—albeit a virtual one in preparation for the real one—then incorporating a social interaction component can begin early in the memory/language/attention process. The acceptance of mirror neurons associated with motor perception has led to an appreciation for similar mirror neurons for empathy which are then used to assess the intentions and mental states of others.13 VR is fertile ground for “parable” training.

  • Executive Decisions

It all comes down to the frontal lobes, where executive decisions are made based on the cognitive functions of it and information preened from the rest of the brain. In other words, frontal lobe function depends on general intellectual ability.14 As such, VR therapy to improve executive decisions is not an independent target, but a beneficiary of all of the above targets of therapy.  

Summary

VR offers adjunctive therapy to conventional therapy and can be tweaked, intensified, simplified, and even administered for reinforcement of gains accomplished. This makes sense in the care of those who are en route to mortality with a fatal disease, because the time-urgency makes dementia an emergency. Rewiring together neurons that have become unwired makes virtual immersion easy, convenient, safe, and engaging. There is no downside. For those who suffer dementia VR can be an important, if not crucial, therapeutic activity whether implemented at home, in a facility, or in outpatient programs.

 

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Resources
  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), American Psychiatric Association, Arlington 2013.
  2. Caselli RJ. (2003). Current issues in the diagnosis and management of dementia. Semin Neurol, 23, 231.
  3. L’Ecuyer, C. (2014). The wonder approach to learning. Frontiers in human neuroscience, 8, 764.
  4. Pearce JMS. Alzheimer's Disease and Related Disorders. British Medical Bulletin Vol 42 Number 1. J Neurol Neurosurg Psychiatry. 1987;50(2):244.
  5. Cheung, K. L., Tunik, E., Adamovich, S. V., & Boyd, L. A. (2014). Neuroplasticity and virtual reality. In Virtual Reality for Physical and Motor Rehabilitation (pp. 5-24). Springer, New York, NY.
  6. Spector, A., Davies, S., Woods, B., & Orrell, M. (2000). Reality orientation for dementia: a systematic review of the evidence of effectiveness from randomized controlled trials. The Gerontologist, 40(2), 206-212.
  7. Davidson, L., & Strauss, J. S. (1992). Sense of self in recovery from severe mental illness. British Journal of medical psychology, 65(2), 131-145.
  8. Bergdahl, E., Allard, P., and Gustafson, P. (2011). Depression among the very old with dementia. International Psychogeriatrics, 23(05), 756.
  9. Waite, A., Bebbington, P., Skelton‐Robinson, M., & Orrell, M. (2004). Life events, depression and social support in dementia. British Journal of Clinical Psychology, 43(3), 313-324.
  10. Doidge, N. (2007). The brain that changes itself: Stories of personal triumph from the frontiers of brain science. Penguin.
  11. Joja, D. O. (2002). Learning experience and neuroplasticity–a shifting paradigm. Nature Reviews Neuroscience, 3(1), 65-71.
  12. Kohler, E., Keysers, C., Umilta, M. A., Fogassi, L., Gallese, V., & Rizzolatti, G. (2002). Hearing sounds, understanding actions: action representation in mirror neurons. Science, 297(5582), 846-848.\
  13. Rizzolatti, G., & Sinigaglia, C. (2007). Mirror neurons and motor intentionality. Functional Neurology, 22(4), 205.
  14. Obonsawin, M. C., Crawford, J. R., Page, J., Chalmers, P., Cochrane, R., & Low, G. (2002). Performance on tests of frontal lobe function reflect general intellectual ability. Neuropsychologia, 40(7), 970-977.
Phil Ashwell

Written by Phil Ashwell

Phil Ashwell is Partnership Manager here at Rescape. He's always been a bit of tech geek, but is not much of a gamer; his era was much more Space Invaders and Mission Control (having a Atari 2600). There is nothing he loves more than introducing people to the DR.VR experiences, especially those who’ve never tried VR before. He is especially pleased to be able to work with DR.VR as he says "it really helps people, really helps them with pain, stress and anxiety, it’s amazing."